Glucose Effectiveness in Obese Children: Relation to Degree of Obesity and Dysglycemia
نویسندگان
چکیده
OBJECTIVE Impaired glucose effectiveness (GE) plays a role in the deterioration of glucose metabolism. Our aim was to validate a surrogate of GE derived from an oral glucose tolerance test (OGTT) and to assess the impact of degrees of obesity and of glucose tolerance on it. RESEARCH DESIGN AND METHODS The OGTT-derived surrogate of GE (oGE) was validated in obese adolescents who underwent an OGTT and an intravenous glucose tolerance test (IVGTT). We then evaluated anthropometric determinants of the oGE and its impact on the dynamics of glucose tolerance in a cohort of children with varying degrees of obesity. RESULTS The correlation of oGE and IVGTT-derived GE in 98 obese adolescents was r = 0.35 (P < 0.001) as a whole and r = 0.51 (P < 0.001) in subjects with normal glucose tolerance. In a cohort of 1,418 children, the adjusted GE was associated with increasing obesity (P < 0.001 for each category of obesity). Quartiles of oGE and the oral disposition index were associated with 2-h glucose levels (P < 0.001 for both). Among 421 nondiabetic obese subjects (276 subjects with normal glucose tolerance/145 subjects with impaired glucose tolerance who repeated their OGTT after a mean time of 28 ± 16 months), oGE changes were tightly associated with weight (r = 0.83, P < 0.001) and waist circumference changes (r = 0.67, P < 0.001). Baseline oGE and changes in oGE over time emerged as significant predictors of the change in 2-h glucose levels (standardized B = -0.76 and B = -0.98 respectively, P < 0.001 for both). CONCLUSIONS The oGE is associated with the degree of and changes in weight and waist circumference and is an independent predictor of glucose tolerance dynamics.
منابع مشابه
Comparative survey of parents'BMI in obese and non-obese 6 - 12 year old children in Esfahan, 2000
Introduction: Child obesity is an issue which deserves attention because it can cause medical ‎problem in children and adults and it tends to sustain which becomes chronic and causes ‎several health risks in adulthood. In recent years, the increasing prevalence of obesity in ‎children has become an important issue in different parts of world. Therefore diagnosis of ‎child obesit...
متن کاملDietary Habits and Cardiometabolic Health in Obese Children
BACKGROUND Prevalence rates of cardiometabolic risk factors vary largely among overweight children. This study investigated the relationships between dietary habits and cardiometabolic health among obese children living in a city of Northern Italy. METHODS Dietary habits were collected in 448 obese subjects aged 6-18 years, attending an obesity outpatient center in Milan. Anthropometry, blood...
متن کاملPrevalence and concomitants of glucose intolerance in European obese children and adolescents.
OBJECTIVE The worldwide increase in the prevalence of childhood obesity is reaching epidemic proportions and is associated with a dramatic rise in cases of type 2 diabetes. The prevalence of glucose intolerance and its determinants and the relation of cardiovascular risk factors with levels of glycemia and degree of obesity were studied in grossly obese children of European origin. RESEARCH D...
متن کاملEvaluation of Nonfasting Tests to Screen for Childhood and Adolescent Dysglycemia
OBJECTIVE To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit one, they arrived fasting and a 2-h glucose tolerance test and HbA(1c) and ...
متن کاملMediation Role of Parental Nutrition Style in Relation with Parental Coping Strategies and Pediatric Obesity in Shiraz, 2019
Objective: In obese children, there is a greater likelihood that they will become obese adults, and they will have negative physical and psychological outcomes. The aim of this study was to determine the mediating role of parental nutritional style in the relationship between parental coping styles and childhood obesity. Materials and Methods: The present study was descriptive and correlationa...
متن کامل